Download E-books Signal Transducers and Activators of Transcription (STATs): Activation and Biology PDF

By James E. Darnell Jr. (auth.), Pravin B. Sehgal, David E. Levy, Toshio Hirano (eds.)

The yr 2003 marks the 10th anniversary of the 1st use of the acronym "Stat" (also written "STAT") within the clinical literature for a kin of transcription components which quickly transduce cytokine-and progress issue­ elicited indications from the plasma membrane to the phone nucleus thereby activating gene transcription (thus, . s. ignal Transducers and Activators of Transcription). From these beginnings, the sphere of STAT transcription elements, their comparable regulatory molecules and their biology has grown exponentially in lots of various instructions. In acceptance of the speedy development and large scope of the STAT transcription issue box this day, and to have fun the 10th anniversary of using this time period within the medical literature, Kluwer educational Publishers B. V. asked us to bring together a quantity on STAT transcription elements that can function an outline of this burgeoning region. hence, we would have liked a quantity that may function a reference for what's recognized approximately STAT proteins and their biology, might describe the present kingdom of ongoing study during this large zone, and could glance towards the long run to aim to foretell the discoveries that lie forward. Our cost was once to find the superior specialists within the box and to coax them to in short summarize their components of expertise.

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