This quantity offers certain descriptions of winning and novel thoughts utilized by specialists within the research of PTEN functionality in affliction and biology. The e-book starts off with chapters exploring how to observe expression degrees of PTEN in general and diseased human specimens; the right way to review particular PTEN functionality in mind melanoma; tools that make the most of a brand new biosensor to degree PTEN legislation; and strategies to degree post-transcriptional law of PTEN by way of micoRNAs and ceRNAs. different chapters current tools describing novel thoughts to notice PTEN localization and formerly unstudied structural beneficial properties of PTEN measured via X-Ray Crystallography and Hydrogen Deuterium alternate Mass Spectrometry. The ebook concludes with the way to research PTEN functionality in version organisms together with mice and C. elegans. Written within the hugely successful Methods in Molecular Biology series layout, chapters comprise introductions to their respective themes, lists of the required fabrics and reagents, step by step, comfortably reproducible laboratory protocols, and tips about troubleshooting and averting identified pitfalls.
Authoritative and thorough, PTEN: equipment and Protocols is a useful selection of methodologies and protocols worthwhile to researchers who're attracted to the PTEN field.
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